Effects of Halofuginone on Fibrosis Formation Secondary to Experimentally Induced Subglottic Trauma

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The aim of the study was to assess the antifibrotic effect of systemically applied halofuginone after subglottic injury.

Materials and Methods:

After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis.


The fibrosis indexes of the treated group were significantly less than those of the control group (P < .01).


Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.

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