Effects of Halofuginone on Fibrosis Formation Secondary to Experimentally Induced Subglottic Trauma

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Abstract

Objective:

The aim of the study was to assess the antifibrotic effect of systemically applied halofuginone after subglottic injury.

Materials and Methods:

After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis.

Results:

The fibrosis indexes of the treated group were significantly less than those of the control group (P < .01).

Conclusions:

Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.

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