Effects of a synbiotic product on blood antioxidative activity in subjects colonized withHelicobacter pylori

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To evaluate the impact of the consumption of a synbiotic product on the antioxidative activity markers of blood in asymptomatic H. pylori-colonized persons.

Methods and Results:

Fifty-three healthy adult volunteers without gastric symptoms participated in a randomized, double-blind placebo-controlled study. The crossover consumption of the enterocoated capsules containing antioxidative Lactobacillusfermentum ME-3, Lact. paracasei 8700:2 and Bifidobacterium longum 46 with Raftilose P95 lasted for 3 weeks and did not change the H. pylori colonization. In H. pylori-positive subjects the sera values of total antioxidative status (TAS) were significantly lower compared to H. pylori-negative subjects (0·97 vs 1·05 mmol l−1, P = 0·008). After the consumption of the synbiotic, TAS values (0·97 vs 1·03 mmol l−1, P = 0·004) increased, while the ratio between oxidized and reduced glutathione (0·035 vs 0·030, P = 0·016) decreased in H. pylori-positive subjects.


The consumption of a synbiotic containing an antioxidative probiotic strain improved the reduced systemic antioxidative activity in H. pylori-colonized asymptomatic subjects.

Significance and Impact of the Study:

A synbiotic product containing an antioxidative probiotic strain may be useful in the reduction of systemic oxidative stress in H. pylori infection.

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