Anti-proliferative effect of two lactic acid bacteria strains of human origin on the growth of a myeloma cell line

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Aims:Twenty lactic acid bacteria strains were isolated from human faeces and tested by MTT assay for stimulation or inhibition of the proliferation of Vero and myeloma cells.Methods and Results:None of the strains significantly affected the proliferation of Vero cells. However, two isolates (HN1 and HA8) showed a strong inhibition of myeloma cell proliferation (16·7 and 5·0%, respectively) by MTT assay.Conclusions:Both strains have an anti-proliferative effect on a tumoral cell line.Significance and Impact of the Study:The beneficial effect of LAB cancer therapy has been linked to their ability for immunomodulation.

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