Utilization of prebiotic carbohydrates by yeasts of therapeutic relevance

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Aims:To investigate 17 strains of therapeutically relevant strains of Saccharomyces cerevisiae (including 10 strains of so-called S. boulardii) isolated from various pharmaceutical products, feed supplements and brewer’s yeast for their capability of utilizing selected carbohydrates of prebiotic importance.Methods and Results:Automated turbidimetric measurements and conventional test combinations were used to examine the basic sugar assimilation profiles of the test strains. It was shown that none of the so-called S. boulardii strains utilized galactose and palatinose. Among the prebiotic substrates, the yeasts indicated a pronounced preference for metabolizing the fructo-oligosaccharides.Conclusions:Yeast strains of therapeutic relevance can be successfully combined with certain prebiotics in synbiotic formulations.Significance and Impact of the Study:The results of this study may serve as a basis for the development of new pharmaceutical preparations for medical therapy and a better understanding of intestinal micro-ecology.

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