Phylogeography ofFrancisella tularensisssp.holarcticain France

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Aim: To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates.Methods and Results:Canonical SNPs and MLVA were used to genotype 103 French F. tularensis ssp. holarctica isolates. We confirmed the presence of one subclade, the central and western European group (B.Br.FTNF002-00), and identified four major MLVA genotypes with no obvious geographical differentiation.Conclusions:The lack of geographical resolution among MLVA genotypes suggests rapid dispersal, convergent evolution or a combination of the two.Significance and Impact of the Study:This study expands knowledge of the phylogeography of one of the two dominant European F. tularensis ssp. holarctica subclades and illustrates the need for additional SNP discovery within this subclade.

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