New chimeric analogues of galanin: Synthesis and effects on the glucose-induced insulin secretion

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The solid-phase synthesis and in vitro assays on the glucose-induced insulin secretion from rat pancreatic islets of Langerhans with six new chimeric peptides were performed. All the peptides were built up of the N-terminal galanin (GAL) fragment or its analogues, linked to the C-terminal portion of substance P (SP) analogues or scyliorhinin I (SCY-I) analogues. Two strong antagonists of the inhibitory effect of galanin on the glucose-induced insulin release were found: [cycloleucine4]GAL(1–13)-SP(5–11)-amide and GAL(1–13)-[L-norleucine10]SCY-I(3–10)-amide.

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