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Common materials used for drug delivery in the body are: liposomes, micelles, polymer capsules, dendrimers, nanoparticles, porous materials, etc. Drug delivery system should be inert, biodegradable, have high biocompatibility and the ability to load large amounts of the drug with known concentration while having a simple and economical sterilizing process. In this study we produced mesoporous silica nanostructures coated with polyamide amine dendrimer that were placed in chitosan-gelatin scaffolds. At every step of the synthesis, the products were identified using different methods, including XRD, FT-IR, SEM, and TGA. The final drug was studied in terms of in vitro & in vivo and MTT toxicity was evaluated.