Could curcumin protect the dendritic trees of the CA1 neurons from shortening and shedding induced by chronic sleep restriction in rats?

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Abstract

Background and objective

This study evaluated the effect of chronic sleep restriction (CSR) with or without curcumin (CUR) treatment on dendritic lengths and spines of the CA1 hippocampus using the virtual space-ball method.

Materials and methods

Male rats were randomly submitted to nine groups, including distilled water, CUR (100 mg/kg/day), olive oil, CSR plus distilled water, CSR plus CUR, CSR plus olive oil, grid-floor plus distilled water, grid-floor plus CUR, and grid-floor plus olive oil groups. Sleep deficiency was imposed using the multi-platform box containing water for 18 h/day. In 21 days, animal's brains were prepared for stereological studies.

Results

The mean dendrite length in CA1 neurons was reduced by 39% (p < 0.05) while the density of stubby, thin, and mushroom spines reduced by 38%, 33% and 32%, respectively (p < 0.01), in the CSR + distilled water group compared to the distilled water group. Yet, CUR treatment in CSR-rats was found to protect the declined dendritic length as well as loss of stubby and mushroom but not thin spines.

Conclusion

The estimated dendritic length using the virtual space-ball method revealed that chronic sleep restriction for 18 h/day over 21 days could induce shortening and shedding of the CA1 dendritic trees which could notably be protected by CUR.

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