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The alkali-induced corneal injury is an ocular emergency that required an immediate and effective management to preserve the normal corneal functions and transparency. Olopatadine is a fast, topically-effective anti-allergic drug, which exhibited potent anti-inflammatory and anti-angiogenic abilities in different allergic animals' models. Therefore, this study aimed to evaluate the therapeutic effect of olopatadine on alkali-induced corneal injury in rats.Corneal alkali injury (CI) induced in the right eyes of an eight-week-old male Wister rats, by application of 3mm diameter filter-papers, soaked for 10s in 1N-NaOH, to the right eyes' corneal centers for 30s, afterward, the filter paper removed, and the rat right eye rinsed with 20ml normal saline. For treatment of CI, either 0.2% or 0.77% olopatadine applied topically daily for 14days, starting immediately after the induction of CI.Olopatadine, in the present work, effectively and dose-dependently enhanced the corneal healing after alkali application, with significant reduction of the corneal opacity and neovascularization scores, besides, it suppressed the augmented corneal IL-1β, VEGF, caspase-3 levels, and nuclear NF-κB immunohistochemical expression, meanwhile it abrogated the corneal histopathological changes, induced by alkali application.Olopatadine appears to be a potential treatment option for alkali-induced corneal injury.