Chronical treatment with sildenafil causes Achilles tendinopathy in rats

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The primary goal was to assess the effects of chronic sildenafil treatment over the Achilles tendons in rats.

Main methods:

Animals were divided into two groups, control and sildenafil administration (n=5). After 60days, the tendons were subject to biochemical and image analysis to compare tendons between the groups: collagen I and decorin content, polarisation microscopy and birefringence analysis, and tissue zymography.

Key findings:

The animals exposed to sildenafil presented a much less organised tendon matrix, with reduced collagen I and non-collagenous protein content and a much higher decorin content.


The results observed in the animals can be characterised as tendinopathy, a condition not yet described as a sildenafil side effect.

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