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Acute myocardial infarction is a tedious risk inherent in all major surgeries. Preoperative assessment has been directed mainly to assess its risk because it carries with it a very high mortality. Living donor liver transplantation has been subject to inquest not only because of the morbidity risk but also because of the mortality risk it carries to the live donor. We report a case of a 39-year-old donor who died of acute myocardial infarction following right-lobe donor hepatectomy. In conclusion, to our knowledge this is the first reported case of mortality due to a cardiac event following donor surgery. Liver Transpl 13:154–156, 2007. © 2006 AASLD.