Effect of free radical scavenger (tempol) on intrarenal oxygenation in hypertensive rats as evaluated by BOLD MRI


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Abstract

PurposeTo demonstrate a differential response following administration of a free radical scavenger, tempol, in kidneys of hypertensive compared to normotensive rats.Material and MethodsData were obtained in spontaneously hypertensive rats (SHR, N = 5). Wistar-Kyoto rats (WKY, N = 6) were used as normotensive controls.ResultsConsistent with prior reports, SHRs show a significant response to tempol (R2*decreased from 40.56 ± 0.66 second−1 to 28.58 ± 0.6 second–1 in medulla, P < 0.05), while WKY rats exhibit a minimal change (R2* measuring 22.36 ± 4.38 second–1 pre-tempol and 21.57 ± 4.78 second–1 post-tempol, in medulla). The post-tempol R2* in SHR was found to be comparable to pre-tempol values in WKY rats, suggesting an improved medullary oxygenation in SHRs.ConclusionBased on both baseline R2* values and the differential effect of the free radical scavenger on renal medullary oxygenation, BOLD MRI can distinguish hypertensive from normal kidney in rats. J. Magn. Reson. Imaging 2005;21:245–248. © 2005 Wiley-Liss, Inc.

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