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To demonstrate the feasibility of three-dimensional (3D) T1ρ-weighted imaging of human knee joint at 3.0T without exceeding the specific absorption rate (SAR) limits and the measurement of the baseline T1ρ values of patellar cartilage and several muscles at the knee joint.3D gradient-echo sequence with a self-compensating spin-lock pulse cluster of 250 Hz power was used to acquire 3D-T1ρ-weighted images of the knee joint of five healthy subjects. Global and regional analysis of patellar cartilage T1ρ were performed. Furthermore, T1ρ of several periarticular muscles were analyzed.The global average T1ρ value of the patellar cartilage varied from 39 to 43 msec. The regional average T1ρ values varied from 38 to 42 msec, and from 42 to 44 msec for medial and lateral facets, respectively. In vivo reproducibility of average T1ρ of patellar cartilage was found to be 5% (coefficient of variation). Similarly, the global average T1ρ values for biceps femoris, lateral gastrocnemius, medial gastrocnemius, and sartorius varied between 31–46, 29–49, 35–48, and 32–50 msec, respectively.We demonstrated the feasibility of 3D-T1ρ-weighted imaging of the knee joint at 3.0T without exceeding SAR limits.