T1 andT2 Measurements of the Fine Structures of the In Vivo and Enucleated Human Eye


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Abstract

Purpose:To measure T1 and T2 of the fine structures of the in vivo eye.Materials and Methods:Involuntary saccades make it difficult to obtain artifact-free images. Using a method recently reported (Bert et al, Acad Radiol 2006;12:368–378), near artifact-free spin-echo images were obtained. Both an isolated enucleated eye and eight human subjects were studied at 1.5T. Spin-echo variable TR/TE data was acquired for T1/T2 determination. Average relaxation times were calculated two ways. First, an arithmetic average over different subjects was computed. Second, all data was normalized using the fitted amplitudes of each data set and pooled to obtain a single least squares fit.Results:In vivo T1/T2 (msec) are: arithmetic average T1, T2, normalized data T1, T2. Anterior chamber: 6233 ± 979, 468 ± 149, 5053 ± 1052, 450 ± 49. Ciliary body: 1916 ± 184, 80 ± 7, 2038 ± 114, 76 ± 3. Chorioretina: 1717 ± 500, 72 ± 25, 1511 ± 230, 78 ± 3. Extraocular muscle: 1581 ± 646, 41 ± 7, 1470 ± 231, 41 ± 1. Iris: 3334 ± 989, 163 ± 63, 3376 ± 338, 153 ± 10. Lens cortex: 1712 ± 466, 93 ± 36, 1413 ± 177, 100 ± 5. Lens nucleus: 1133 ± 40, 26 ± 3, 1138 ± 47, 25 ± 0.4. Optic nerve: 1906 ± 301, 68 ± 16, 1805 ± 244, 71 ± 2. Posterior chamber: 7915 ± 4897, 241 ± 14, 3323 ± 2154, 251 ± 38. Vitreous humor: 5768 ± 1190, 756 ± 804, 4855 ± 1846, 390 ± 8.Conclusion:In vivo T1 and T2 for many of the fine structures of the human eye have been measured.

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