Relationship Between the Renal Apparent Diffusion Coefficient and Glomerular Filtration Rate: Preliminary Experience

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Purpose:To investigate the relationship between ADC values measured by diffusion-weighted MRI (DWI) and the split glomerular filtration rate (GFR).Materials and Methods:DWI (b = 0 and 500 seconds/mm2) was performed with a 1.5T MR unit in 55 patients. The ADCs were calculated with ROIs positioned in the renal parenchyma, and the split GFRs were measured by 99Tcm-DTPA scintigraphy using Gates' method. The 110 kidneys were divided into four groups: normal renal function (GFR 40 mL · minute−1), mild renal impairment (40 > GFR ≥ 20 mL · minute−1), moderate renal impairment (20 > GFR ≥ 10 mL · minute−1), and severe renal impairment (GFR < 10 mL · minute−1). The renal ADCs between four groups were statistically compared by analysis of variance (ANOVA), and the relationship between ADCs and GFR was examined using Pearson's correlation test.Results:The mean renal ADCs of the four groups were 2.87 ± 0.11, 2.55 ± 0.17, 2.29 ± 0.10, and 2.20 ± 0.11 × 10−3mm2/second, respectively. There was a statistically significant difference in renal ADCs among the four groups (P < 0.001). There was a positive correlation between the ADCs and split GFR (r = 0.709).Conclusion:The ADCs were significantly lower in impaired kidneys than in normal kidneys, and there was a positive correlation between the ADCs and GFR.

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