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To evaluate the feasibility of using manganese-based MR imaging contrast agent EVP-ABD to detect diffuse liver disease in an established rat hepatitis model.Hepatitis was induced by administration of CCl4 in corn oil vehicle to rats intraperitoneally. MR images were acquired on a 3T scanner using a volume coil ≈36 hours after the administration of CCl4. EVP-ABD was administered via a tail vein at a dose of 10 μmol/kg. Multi-TI turboflash images were acquired to evaluate liver R1 (=1/T1) values before and after the EVP-ABD administration. Eighteen rats received various doses of CCl4 and completed pre- and postcontrast MRI scans and liver histologic evaluation.The liver R1 after the EVP-ABD administration and the change of the liver R1 before and after the administration, ΔR1, show significant correlations with the CCl4 dose. A significant correlation was also found between the histologic scores and the CCl4 doses despite known variability in the relationship of CCl4 dose to histology. A significant correlation was found between the histologic score and ΔR1.Our results indicate that EVP-ABD-enhanced MRI can detect diffuse liver disease generated by CCl4 based on the significant correlation between proton R1 in liver following EVP-ABD and the CCl4 doses as well as the histologic scores. J. Magn. Reson. Imaging 2008;27:1317–1321. © 2008 Wiley-Liss, Inc.