AccurateT1 mapping for oxygen-enhanced MRI in the mouse lung using a segmented inversion-recovery ultrashort echo-time sequence

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Purpose:A segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T1 mapping of mouse lung in vivo.Methods:Numerical simulations were performed to estimate T1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen.Results:The simulations demonstrated the high potential of the technique for accurate and precise T1 assessment. Phantom experiments showed good agreement for T1 values measured with segmented inversion-recovery ultrashort echo-time and the reference technique. The in vivo experiment demonstrated the utility of the technique in oxygen-enhanced assessment, where small T1 changes were detected with high precision.Conclusion:Segmented inversion-recovery ultrashort echo-time provides accurate, high resolution T1 mapping of the lung parenchyma. Magn Reson Med 71:2180–2185, 2014. © 2013 Wiley Periodicals, Inc.

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