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To evaluate the performance of an advanced method for correction of inhomogeneous static magnetic field induced distortion in echo-planar imaging (EPI), applied to diffusion-weighted MRI (DWI) of the breast.An algorithm for distortion correction based on the symmetry of the distortion induced by static field inhomogeneity when the phase encoding polarity is reversed was evaluated in 36 data sets of patients who received an MRI examination that included DWI (b = 0 and 700 s/mm2) and an extra b = 0 s/mm2 sequence with opposite phase encoding polarity. The decrease of the L2-square norm after correction between opposed phase encoding b = 0 images was calculated. Mattes mutual information between b = 0 images and fat-suppressed T2-weighted images was calculated before and after correction.The L2-square norm between different phase encoding polarities for b = 0 images was reduced 94.3% on average after distortion correction. Furthermore, Mattes mutual information between b = 0 images and fat-suppressed T2-weighted images increased significantly after correction for all cases (P < 0.001).Geometric distortion correction in DWI of the breast results in higher similarity of DWI to anatomical non-EPI T2-weighted images and would potentially allow for a more reliable lesion segmentation mapping among different MRI modalities. Magn Reson Med 74:1138–1144, 2015. © 2014 Wiley Periodicals, Inc.