This article is based on a lecture presented in the Symposium on Ventilatory Control During Exercise at the 24th Annual Meeting of the American College of Sports Medicine, May 25-28, 1977, Chicago, Illinois.
SUTTON, JOHN R. and NORMAN L. JONES. Respiratory control during exercise: mediators in the blood — CO2 and hydrogen ion. Med. Sci. Sports. Vol. 11, No. 2, pp. 198-203, 1979. In reviewing the blood borne “mediators” to ventilation during exercise, our emphasis is on Vco2 and [H+]. We cknsider that exercise ventilation is more closely linked to Vco2 than to Vo2. Lactic acid has a dual effect on ventilation, as it results in an increased CO2 output as well as increased [H+], an independent ventilatory stimulus. Examples from acid-base disturbances hypoxia and training are used to illustrate the relationship of VE to Vco2 and [H+].