Typical and atypical antipsychotics drug-induced agranulocytosis and neutropenia: a case report

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Agranulocytosis is an idiosyncratic reaction that usually occurs in the first 3–4 weeks of treatment with psychotropic drugs, particularly with clozapine. All psychotropic drugs have been associated with blood dyscriasis [1&2]. White blood cells (WBCs) are affected most commonly resulting in neutropenia (neutrophils <1500 μl) or agranulocytosis (neutrophils <500 μl). The drug-induced dyscriasis might be caused by direct toxic effect on bone marrow, peripheral destruction, or antibody formation against hematopoietic cells or its precursors.

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