Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone: A case report

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Primary lymphomas of the uterine cervix are a rare disease. They are often misdiagnosed because of their rarity and because they can be easily confused with a squamous cell carcinoma of the cervix, as they are usually presented as exophytic mass with vaginal bleeding as their most common symptoms. Nevertheless, considering that both the prognosis and the treatment are completely different between them, differential diagnosis should be taken into account.

Patient concerns:

A case of a 51-year-old woman with a primary diffuse large B-cell lymphoma of the cervix is presented.


Diagnosis of this tumor was a challenge for pathologists and clinicians, as four biopsies were needed to achieve a final diagnosis.


Patient was successfully treated with combined Rituximab and chemotherapy (R-CHOP) alone.


Complete remission, confirmed through biopsy, was reached after six courses of chemotherapy. At 2-years follow up, patient is alive and free of disease.


Considering that the prognosis and treatment of primary malignant lymphoma of the cervix are completely different than that of the squamous cell carcinoma, awareness of this disease should be considered in the differential diagnosis.

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