Bone marrow necrosis secondary to metastatic adenocarcinoma revealed by 18F-FDG PET/CT: A clinical case report


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Abstract

Rationale:Bone marrow necrosis (BMN) is a rare malignancy-associated hematologic disorder characterized by necrosis of myeloid and stromal marrow elements with preservation of cortical bone.Patient concerns:A 43-year-old female complaining of dizziness and vaginal bleeding for more than 2 months was presented to our department.Diagnosis:Due to the laboratory test results, radiographic findings, especially 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) which revealed that bone marrow was characterized by diffuse 18F-FDG uptake with extensive central photopenia, and pathologic results, she was diagnosed with metastatic adenocarcinoma accompanied with BMN. And the cancer most likely originated from reproductive system or breast.Interventions:There was no effective interventions for her before knowing the accurate origin of adenocarcinoma.Outcomes:Two weeks later, unfortunately, she died.Lessons:18F-FDG PET/CT is a useful diagnostic modality in patients with BMN. Malignant tumor should always be considered in patients with extensive BMN, even in young people.

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