Endostar combined with chemotherapy in a pediatric osteosarcoma with pulmonary metastasis and malignant pleural effusion: A case report

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Abstract

Rationale:

Angiogenesis is a key factor for tumor growth and metastasis both in cancer and sarcoma. Endostar, a novel safe and well-tolerated recombinant human endostatin, can suppress the expression of VEGF and the activation of ERK, MAPK, and AKT, and then inhibit tumor progression.

Patient concerns:

A pediatric osteosarcoma with pulmonary metastasis and malignant pleural effusion.

Diagnoses:

Osteosarcoma with pulmonary metastasis and malignant pleural effusion.

Interventions:

Considering the physical condition of patient, the patient underwent surgical resection of the right lung lesion after receiving endostar combined with chemotherapy and maintained endostar alone for 47 cycles.

Outcomes:

The patient obtained pathologic complete remission and had been in progression-free survival up to now.

Lessons:

Our experience could provide a treatment strategy for pediatric osteosarcoma patients with pulmonary metastasis and malignant pleural effusion.

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