Improvement of chronic hepatitis B by iron chelation therapy in a patient with iron overload: A case report

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Abstract

Rationale:

This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB.

Patient concerns:

Increased serum ferritin level for 2 months.

Diagnosis:

Secondary iron overload and CHB.

Intervention:

To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy. During the therapy, serum ferritin and hepatitis B virus (HBV) were monitored and the iron concentration of the liver and heart were followed by T2* of magnetic resonance imaging (MRI) scan.

Outcomes:

Serum ferritin gradually decreased. Approximately 1 year after the therapy, HBsAg turned persistently negative.

Lessons:

Iron chelation therapy may attenuate HBV infection.

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