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Tumor necrosis factor-alpha (TNF-α) is an important cytokine and has been reported to be associated with the pathogenesis of many autoimmune and inflammatory diseases. TNF-α gene is located on a region that has been found to be associated with obsessive-compulsive disorder (OCD). We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-α-238G/A gene polymorphism.An extensive search of the available literature on the association between the susceptibility to OCD and the TNF gene polymorphism was conducted by searching PubMed, Web of Knowledge, Embase, Chinese Web of Knowledge, Wanfang, and Chongqing VIP database. The database was searched up to December 2016 and includes language of English and/or Chinese with the keywords of “obsessive-compulsive disorder” or “OCD,” polymorphism or variant or mutation, “tumor necrosis factor” or “TNF” or “cytokine.” The association between TNF-α-238G/A gene polymorphism and the susceptibility of OCD was anticipated by odds ratio (OR) with the corresponding 95% confidence interval (95% CI).Four studies including 435 cases and 1073 controls were incorporated in our meta-analysis. In general, TNF-α-238G/A gene polymorphism might lead to a decreased risk of OCD susceptibility (G vs A genotype model: OR = 1.01, 95% CI = 0.37–2.77, P = .981; GG vs AA+AG model: OR = 0.93, 95% CI = 0.37–2.36, P = .879; GG+AG vs AA model: OR = 0.22, 95% CI = 0.06–0.73, P = .014; GG vs AA model: OR = 0.21, 95% CI = 0.06–0.71, P = .012; AG vs AA model: OR = 0.29, 95% CI = 0.07–1.16, P = .081; GG+AA vs AG model: OR = 1.17, 95% CI = 0.55–2.51, P = .683).TNF-α-238G/A gene polymorphism might lead to a decreased risk of OCD susceptibility.