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Elevated levels of blood lipids are well-documented risk factors for cardiovascular disease. For cardiovascular risk reduction, preventive strategies to lower blood cholesterol levels are essential, and these strategies include lifestyle modification and cholesterol-lowering agents. We aim to investigate the cholesterol-lowering effects and safety of yellow yeast rice in a randomized, controlled, double-blind, and parallel group study.Participants for this study will be selected based on the following inclusion criteria:Voluntary agreement to participate and sign the written informed consent formsMen and women (aged 20–45 years, premenopause)Body mass index: 18 to 30 kg/m2Fasting low-density lipoprotein cholesterol (LDL-C) levels: ≥130 mg/dLFasting triglyceride levels: <300 mg/dLParticipants are randomly allocated to the placebo or yellow-yeast-rice-treated group. Participants with mild to moderately elevated LDL-C levels will consume 1 pouch of yellow yeast rice powder (containing monacolin K) or placebo twice daily for 8 weeks. Next, the lipid profiles will be evaluated.The number of participants required for this study is 68, and is currently recruiting participants. Participants are randomly assigned to control group and intervention group.This is the first human intervention study to investigate the cholesterol-lowering effects and safety of yellow yeast rice in adults with mild to moderate hypercholesterolemia. Also, this is a randomized, double-blind, placebo-controlled trial that considers confounders, such as dietary habits, lifestyle factors, and genetic factors.