Spontaneous regression of locally advanced nonsmall cell lung cancer: A case report

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Spontaneous regression of non-small cell lung cancer is exceptionally rare.

Patient concerns:

Treatment-related toxicity.


We report a case of a patient diagnosed with locally advanced non-small cell lung cancer.


The patient declined potentially curative treatment, and did not receive any anti-cancer treatment.


He has survived more than two years since his initial diagnosis, maintaining his good performance status. Serial imaging with computed tomography scans showed tumour regression and near-complete resolution of his disease.


Spontaneous regression of non-small cell lung cancer, by virtue of its scarcity, has not been well-studied and is poorly understood. Further studies are required, in order to clarify the mechanisms by which spontaneous regression occurs, and possibly identify new targets for cancer treatment.

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