Mediastinal and retroperitoneal fibrosis as a manifestation of breast cancer metastasis: A case report and literature review

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Abstract

Rationale:

Mediastinal and retroperitoneal fibrosis as a manifestation of metastasis from malignancies is rare disease and particularly, cases of mediastinal fibrosis have been rarely reported.

Patient concerns:

A 60-year-old woman presented with dyspnea and bilateral flank pain. The patient had no previous history of malignancy.

Diagnoses:

A contrast-enhanced chest computed tomography scan revealed a left breast mass and infiltrative soft tissue masses in the mediastinum and retroperitoneum, which showed high fluorodeoxyglucose uptake on positron emission tomography scan. The left breast mass was proven as a malignancy on biopsy and surgical excisional biopsy of the mediastinal mass revealed metastasis from the breast cancer on histopathologic examination.

Interventions:

Our patient was treated with palliative hormone therapy for the primary breast cancer and metastasis with mediastinal and retroperitoneal fibrosis.

Outcomes:

Follow-up imaging studies showed improvement of the primary breast cancer and also metastasis.

Lessons:

We report this rare case to emphasize that mediastinal and retroperitoneal fibrosis can be a presentation of metastasis from various primary malignancies. We expect that appropriate diagnosis and treatment for metastatic mediastinal and retroperitoneal fibrosis can have a beneficial effect on disease course and prognosis of the patient.

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