Multiple myeloma with pathologically proven skull plasmacytoma after a mild head injury: Case report

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Rationale:MM is a malignant tumor originating from the plasma cells of the bone marrow. Central nervous system myelomatosis is very rare and may be a complication of MM.Patient concerns:A 60-year-old man presented with a slowly growing soft mass at his right frontal scalp after a mild head injury 6 months ago.Diagnoses:Neuroradiological examinations revealed a solid intracranial-extracranial mass with an osteolytic lesion in the skull. Histopathological examination showed skull plasmacytoma, and postoperative examinations revealed multiple myeloma.Interventions:The tumor was completely removed and the skull defect repaired with the titanium mesh. Then, chemotherapy was initiated after surgery with bortezomib and dexamethasone.Outcomes:The patient received eight chemotherapies within one year after surgery.Lessons:Despite a history of head injury, a differential diagnosis should be kept in mind during the diagnosis of solid intracranial-extracranial masses, especially in the presence of osteolytic skull at the lesioned site.

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