Primary squamous cell carcinoma of the pancreas with effective comprehensive treatment: A case report and literature review

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Primary squamous cell carcinoma (SCC) of the pancreas is a rare entity since the pancreas lacks squamous cells. This condition is associated with a poor prognosis, and there is currently no optimal treatment strategy for it.

Patient concerns:

A 64-year-old female patient with a complaint of epigastric pain for 3 months was referred to our hospital.


She was finally diagnosed with primary SCC of the pancreas with lymph node metastasis on the basis of radiological and pathological findings.


She received chemoradiation along with targeted therapy and was provided with treatment response evaluation through PET/CT.


She eventually died of tumor progression after 8 months.


Primary SCC of the pancreas is associated with a poor prognosis. Comprehensive therapy and proper radiologic evaluation may facilitate prolonged survival of these patients.

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