Serum visfatin level in obese Egyptian children and adolescents and its relation with metabolic syndrome

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Abstract

Objective

We aimed to study visfatin level in obesity and its relation with metabolic syndrome (MS).

Patients and methods

This case–control study included 42 obese children and adolescents and 39 age-matched and sex-matched nonobese children who served as controls. Full medical examination and anthropometric measurements were carried out. Fasting serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood sugar, insulin, and visfatin were measured. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated.

Results

Fasting serum visfatin level was significantly higher in obese children and adolescents compared with controls (8.7±2.8 vs. 3.3±2.3 ng/ml, P=0.001). Visfatin showed significant positive correlations with waist circumference (P<0.001), systolic blood pressure (P=0.001), diastolic blood pressure (P=0.01), and fasting blood glucose (P=0.001). Visfatin was significantly higher in obese patients with MS than in patients without MS (10.03±3.2 vs. 7.8±2.2 ng/ml, P=0.02).

Conclusion

Visfatin elevated in obese children. Visfatin might be used as a predictor test for the existence of MS in obese children.

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