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Work undertaken at CMIC, UCL from 2005 to 2015 on the topic of image guided interventions and image guided therapy, with reference to earlier work at CISG, Guy's Hospital, KCL.Shows how a hierarchical approach to computational anatomy in image guided interventions was developed.Illustrated with applications in guiding neurosurgery, detection of colon cancer, planning breast cancer surgery, guiding prostate cancer interventions and image directed lung radiotherapy.This paper describes work at CMIC, UCL from 2005 to 2015 combining clinical imaging and computational models applied to cancer detection and image guided interventions. In particular it shows how we have developed a hierarchical approach to multiscale computational anatomy for image guided interventions.This short paper describes the development of the UCL Centre for Medical Image Computing (CMIC) from 2006 to 2016, together with reference to historical developments of the Computational Imaging sciences Group (CISG) at Guy's Hospital. Key early work in automated image registration led to developments in image guided surgery and improved cancer diagnosis and therapy. The work is illustrated with examples from neurosurgery, laparoscopic liver and gastric surgery, diagnosis and treatment of prostate cancer and breast cancer, and image guided radiotherapy for lung cancer.