MUTTON, D. L., S. F. LOY, D. M. ROGERS, G. J. HOLLAND, W. J. VINCENT, and M. HENG. Effect of run vs combined cycle/ run training on VO2max and running performance. Med. Sci. Sports Exerc., Vol. 25, No. 12, pp. 1393–1397, 1993. The effects of 5 wk of equivalent intensity, 85–90% maximum heart rate (MHR), run-only (N = 6) vs cycle/run (N = 5) training were evaluated in moderately fit runners, mean JOURNAL/mespex/04.02/00005768-199312000-00013/ENTITY_OV0312/v/2017-07-20T222403Z/r/image-pngO2max of 55.2 ml.kg-1.min-1, 19–35 yr old, on maximal treadmill (TM) and cycle ergometer (CE) testing, 5000-m and 1609-m run performances, and submaximal measures while treadmill running. Subjects participated in either 4 d.wk-1 of run-only or alternating run and cycle training. Both groups significantly improved TM JOURNAL/mespex/04.02/00005768-199312000-00013/ENTITY_OV0312/v/2017-07-20T222403Z/r/image-pngO2max (P < 0.05), CE JOURNAL/mespex/04.02/00005768-199312000-00013/ENTITY_OV0312/v/2017-07-20T222403Z/r/image-pngO2peak (P < 0.01), and 5000-m (P < 0.01) and 1609-m (P < 0.05) run times with no significant differences between the groups. The TM JOURNAL/mespex/04.02/00005768-199312000-00013/ENTITY_OV0312/v/2017-07-20T222403Z/r/image-pngO2max pre/post values were 55.3 ± 3.0 to 58.2 ± 3.0 and 55.6 ± 3.8 to 58.9 ± 2.4 ml.kg-1.min-1 for the run group and cross-trained group, respectively. Posttraining submaximal treadmill running showed statistically significant pace increases of 18.7 (run) and 16.1 (cycle/run) m.min-1 with similar heart rate, blood lactate, and RQ values as pretraining. Results indicate that 5 wk of either mode of training can significantly improve aerobic capacity and run performance.