Fibroblast responses to variation in soft tissue mobilization pressure

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The purpose of this study was to determine morphologic changes in the rat Achilles tendon after enzyme-induced injury with collagenase and subsequent pressure variations in ASTM therapy.


Thirty male white rats were randomly assigned to one of five groups with six animals per group: tendinitis (A), tendinitis plus light ASTM (B), tendinitis plus medium ASTM (C), tendinitis plus extreme ASTM (D), and control with surgery only (E). ASTM was performed for 3 min, for a total of six treatment sessions. The Achilles tendons of each group were harvested 1 wk after the last ASTM treatment. Fibroblast numbers were assessed by light microscopy. An electron microscope was used to observe enlargement of fibroblasts.


Statistical analysis of the number of fibroblasts present indicated a significant difference (P < 0.00) between group D and all other groups.


The morphological evidence indicated that the application of heavy pressure promoted the healing process to a greater degree than light or moderate pressure.

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