Combined Exercise Training Improves Glycemic Control in Adult with Cystic Fibrosis

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Abstract

Purpose

Glucose abnormality and diabetes are the most common comorbidities in cystic fibrosis (CF). Combined (aerobic and resistance) exercise program in type 2 patients with diabetes demonstrated an improvement of glycemic control. The aim of the study was to determine whether a combined exercise program is beneficial to improve plasma glucose at 2 h of the oral glucose tolerance test in CF.

Method

Eighteen adults with CF with glucose abnormality were recruited (Clinicaltrial.gov: NTC02127957), and 17 were randomly assigned to a control or exercise group for 12 wk. V˙O2max, oral glucose tolerance test, muscular endurance and strength, and quality of life were measured pre- and postintervention.

Results

Fourteen participants completed the protocol. Patients in the exercise group improved significantly their 2-h plasma glucose values (−2.34 ± 1.26 mmol·L−1, P < 0.007, confidence interval = 99.22%) and presented a reduction of 17.2% (P < 0.05) in total glucose excursion. No significant change for other parameters was observed.

Conclusion

A combined exercise program improves glycemic control in CF.

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