Nil Whey Protein Effect on Glycemic Control after Intense Mixed-Mode Training in Type 2 Diabetes

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This study aimed to determine if peritraining whey protein supplementation combined with MMIT can improve glycemic control.


In a double-blind, randomized, placebo-controlled trial, 24 men (55.7 ± 5.6 yr) with T2D performed MMIT with whey (20 g) or placebo control for 10 wk. Glycemic control was assessed via glucose disposal rate during a euglycemic insulin clamp, fasting blood glucose concentration, and homeostatic model assessment of insulin resistance. Changes in peak oxygen consumption, 1-repetition maximum strength, vastus lateralis muscle, and subcutaneous adipose thicknesses, and waist circumference were also assessed.


Ten weeks of MMIT substantially improved glucose disposal rate by 27.5% (90% confidence interval, 1.2%–60.7%) and 24.8% (−5.4% to 64.8%) in the whey and control groups, respectively. There were likely and possible reductions in fasting blood glucose by −17.4% (−30.6% to −1.6%) and homeostatic model assessment of insulin resistance by −14.1% (−25.3% to 1.08%) in the whey group; however, whey effects were not clearly beneficial to glycemic outcomes relative to the control. MMIT also clearly substantially improved 1-repetition maximum by 20.6% (16.3%–24.9%) and 22.7% (18.4%–27.2%), peak oxygen consumption by 22.6% (12.0%–26.2%) and 18.5% (10.5%–27.4%), and vastus lateralis muscle thickness by 18.9% (12.0%–26.2%) and 18.6% (10.5%–27.4%) and possibly reduced waist circumference by −2.1% (−3.1% to −1.0%) and −1.9% (−3.7% to −0.1%) in the control and whey groups, respectively, but the whey–control outcome was trivial or unclear.


A clinically meaningful enhancement in glycemic control after 10 wk of MMIT was not clearly advanced with peritraining whey protein supplementation in middle-age men with T2D.

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