Accumulation of major histocompatibility complex class II+CD11c− non-lymphoid cells in the spleen during infection withPlasmodium yoeliiis lymphocyte-dependent

    loading  Checking for direct PDF access through Ovid


The spleen is the main organ for immune defense during infection withPlasmodiumparasites and splenomegaly is one of the major symptoms of such infections. Using a rodent model ofPlasmodium yoeliiinfection, MHC class II+CD11c− non-T, non-B cells in the spleen were characterized. Although the proportion of conventional dendritic cells was reduced, that of MHC II+CD11c− non-T, non-B cells increased during the course of infection. The increase in this subpopulation was dependent on the presence of lymphocytes. Experiments using Rag-2−/− mice with adoptively transferred normal spleen cells indicated that these cells were non-lymphoid cells; however, their accumulation in the spleen during infection withP. yoeliidepended on lymphocytes. Functionally, these MHC II+CD11c− non-T, non-B cells were able to produce the proinflammatory cytokines alpha tumor necrosis factor and interleukin-6 in response to infected red blood cells, but had only a limited ability to activate antigen-specific CD4+ T cells. This study revealed a novel interaction between MHC II+CD11c− non-lymphoid cells and lymphoid cells in the accumulations of these non-lymphoid cells in the spleen during infection withP. yoelii.

Related Topics

    loading  Loading Related Articles