Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects

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Low adiponectin levels have been associated with obesity, diabetes, coronary disease and polymorphisms. The aim of this study was to assess the clinical and genetic factors related to adiponectin levels in a Chilean adult population.


Four groups of 27 individuals, stratified by gender and abdominal obesity, were included in this crosssectional study. Physical activity level, cardiovascular risk factors and therapy were assessed. Anthropometric measurements, adiponectin, glucose, insulin, hs-CRP, rs1501299, rs2241766, rs266729 and rs17300539 single nucleotide polymorphisms of the adiponectin gene were determined.


Adiponectin levels were inversely correlated with waist circumference, waist-to-hip ratio, weight, body mass index, insulin levels, homeostasis model insulin resistance index (HOMA-IR) and physical activity. Mean adiponectin levels were lower in men (10.1 ± 3.6 vs 11.9 ± 2.9 μg/mL, p = 0.0051), obese (9.9 ± 3.2 vs 12.1 ± 3.3, p < 0.01), physically inactive (8.9 ± 3.2 vs 11.0 ± 2.8, p = 0.015) and insulin-resistant individuals (10.2 ± 3.1 vs 12.9 ± 3.9; p = 0.005). Adiponectin levels were lower in subjects with GG genotype (rs1501299) compared with those with TT or GT variants (6.9 ± 4.6 vs 12.2 ± 2.9 and 11.5 ± 3.4 μg/mL, p = 0.006) but were similar in the other polymorphisms studied.


Lower adiponectin levels were related to gender, abdominal obesity, physical activity and insulin resistance and were less influenced by the polymorphisms studied.

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