CENTB5 Gene Expression in Humans and Mice

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Abstract

Centaurin β5, a protein with a yet unknown function, belongs to the centaurin family. It is encoded by CENTB5, whose expression pattern has been studied insufficiently. Intron 14–15 of human CENTB5 contains a lowly variable minisatellite repeat UPS29, while the mouse Centb5 contains an imperfect microsatellite repeat (CATG)19. The shorter UPS29 alleles have previously been associated with certain forms of Parkinson's disease and epilepsy. Moreover, both human and murine CENTB5 are syntenic with SCNN1D and ACOT7, which are active primarily in the nervous system, and whose aberrations are associated with epilepsy and neurodegenerative processes. As intronic sequences can modulate the expression of not only those genes that harbor them, but also of neighboring and remote genes, the CENTB5, SCNN1D, and ACOT7 expression levels were all analyzed by RT-PCR. The potential of intronic tandem repeats UPS29 and (CATG)19 to regulate/modulate the expression of CENTB5, SCNN1D, and ACOT7 has been assessed in silico. CENTB5, SCNN1D, and ACOT7 expression was detected in all human and murine tissues studied, suggestive of their physiologic importance. The putative role of UPS29 in the regulation of CENTB5, SCNN1D, and ACOT7 activity in the nerve tissue is discussed.

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