Genetic polymorphism of GSTT1 may be under natural selection in a population chronically exposed to natural sour gas

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In order to examine whether chronic exposure to natural sour gas containing sulfur compounds act as natural selection force on genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1), the present study was done.


The study was performed on two groups of healthy individuals of Masjid-i-Sulaiman (Khozestan province, southwest of Iran) citizens with the mean ages of 47.5 ± 12.4 (36 male and 58 female) and 16.3 ± 2.4 (47 male and 140 female) that were considered as first and second generation, respectively. The GSTT1 and GSTM1 genotypes were determined using a PCR-based method.


The genotypic frequencies of GSTM1 did not change significantly (χ2 = 0.085, df = 1, P = 0.770). The frequency of the GSTT1 null genotype was 52.1% in the first generation and reached to 36.4% in the second generation. There was significant difference between two generations for the GSTT1 polymorphism (χ2 = 6.397, df = 1, P = 0.011).


It was suggested that the GSTT1 polymorphism may be under natural selection because of probably favored ability of GSTT1-active genotype to survival and reproduction.

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