Tissue-targeted complement therapeutics

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HighlightsTherapeutic complement inhibitors are approved for treatment of several diseases.Several new complement inhibitors are under development.Targeted complement inhibitors can reduce tissue inflammation without blocking the complement cascade systemically.Targeted complement inhibitors may be more effective than untargeted drugs, and may have fewer side effects.Complement activation contributes to the pathogenesis of numerous inflammatory and autoimmune diseases. Therapeutic complement inhibitors have proven effective in several of these diseases and have now entered clinical use. Complement activation has multiple different biologic effects, however, and the currently available drugs can have undesirable side-effects, such as an increased risk of infection. Several different complement inhibitors have been developed that bind to target molecules, thereby concentrating the drug at a specific anatomic site. This approach appears to be both more effective than untargeted drugs and to have fewer side effects. In this article we review different targeting strategies that have been developed and the evidence supporting the use and benefits of targeted drugs.

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