For non-Cartesian data acquisition in MRI,k-space trajectory infidelity due to eddy current effects and other hardware imperfections will blur and distort the reconstructed images. Even with the shielded gradients and eddy current compensation techniques of current scanners, the deviation between the actualk-space trajectory and the requested trajectory remains a major reason for image artifacts in non-Cartesian MRI. It is often not practical to measure thek-space trajectory for each imaging slice. It has been reported that better image quality is achieved in radial scanning by correcting anisotropic delays on different physical gradient axes. In this article the delay model is applied in spiralk-space trajectory estimation to reduce image artifacts. Then a novel estimation method combining the anisotropic delay model and a simple convolution eddy current model further reduces the artifact level in spiral image reconstruction. The root mean square error and peak error in both phantom and in vivo images reconstructed using the estimated trajectories are reduced substantially compared to the results achieved by only tuning delays. After a one-time calibration, it is thus possible to get an accurate estimate of the spiral trajectory and a high-quality image reconstruction for an arbitrary scan plane. Magn Reson Med, 2009. © 2009 Wiley-Liss, Inc.