Ultra-fast steady state free precession and its application to in vivo 1H morphological and functional lung imaging at 1.5 tesla

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The speed limit for three-dimensional Fourier-encoded steady state free precession (SSFP) imaging is explored on a clinical whole body system and pushed toward a pulse repetition time (TR) close to or even below the 1 ms regime; in the following referred to as ultra-fast SSFP imaging.


To this end, contemporary optimization strategies, such as efficient gradient switching patterns, partial echoes, ramp sampling techniques, and a target-related design of excitation pulses were applied to explore the lower boundaries in TR for SSFP-based Cartesian imaging.


Generally, minimal TR was limited in vivo by peripheral nerve stimulation, allowing a TR ˜1 ms for isotropic resolutions down to about 2 mm. As a result, ultra-fast balanced SSFP provides artifact-free images even for targets with severe susceptibility variations, and native high-resolution structural and functional in vivo 1H imaging of the human lung is demonstrated at 1.5 T.


On clinical whole body MRI systems, the TR of SSFP-based Cartesian imaging can be pushed toward the 1 ms regime. As a result, ultra-fast SSFP protocols might represent a promising new powerful approach for SSFP-based imaging, not only for lung but also in a variety of clinical and scientific applications.

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