Magnetic Resonance in Medicine. 77(6):2288–2295, JUN 2017

DOI: 10.1002/mrm.26319

,  

PMID: 27404992

Issn Print: 0740-3194

Publication Date: 2017/06/01


Share this on facebook   Share this on Twitter   Share this on LinkedIn   Email this article  



Print

Multiple Breath Washout of Hyperpolarized 129Xe and 3He in Human Lungs With Three-Dimensional Balanced Steady-State Free-Precession Imaging

Felix Horn;Madhwesha Rao;Neil Stewart;Jim Wild;

+ Author Information


    loading  Checking for direct PDF access through Ovid

Abstract

Purpose:To compare quantitative fractional ventilation measurements from multiple breath washout imaging (MBW-I) using hyperpolarized 3He with both spoiled gradient echo (SPGR) and balanced steady-state free precession (bSSFP) three-dimensional (3D) pulse sequences and to evaluate the feasibility of MBW-I with hyperpolarized 129Xe.Methods:Seven healthy subjects were scanned using 3He MBW-I with 3D SPGR and bSSFP sequences. Five also underwent MBW-I with 129Xe. A dual-tuned coil was used to acquire MBW-I data from both nuclei in the same subject position, enabling direct comparison of regional information.Results:High-quality MBW images were obtained with bSSFP sequences using a reduced dose (100 mL) of inhaled hyperpolarized 3He. 3D MBW-I with 129Xe was also successfully demonstrated with a bSSFP sequence. Regional quantitative ventilation measures derived from 3He and 129Xe MBW-I correlated well in all subjects (P < 0.001) with mean Pearson's correlation coefficients of r = 0.61 and r = 0.52 for 3He SPGR-bSSFP and 129Xe-3He (bSSFP) comparisons. The average intersubject mean difference (and standard deviation) in fractional ventilation in SPGR-bSSFP and 129Xe-3He comparisons was 15% (28%) and 9% (38%), respectively.Conclusions:Improved sensitivity in MBW-I can be achieved with polarization-efficient bSSFP sequences. Same scan-session 3D MBW-I with 3He and 129Xe has been demonstrated using a dual-tuned coil.

Related Topics

        loading  Loading Related Articles