Protective effect of female gender–related factors on muscle force-generating capacity and fragility in the dystrophicmdxmouse

    loading  Checking for direct PDF access through Ovid

Abstract

Introduction:

The dystrophic features in hindlimb skeletal muscles of femalemdxmice are unclear.

Methods:

We analyzed force-generating capacity and force decline after lengthening contraction-induced damage (fragility).

Results:

Young (6-month-old) femalemdxmice displayed reduced force-generating capacity (−18%) and higher fragility (23% force decline) compared with female age-matched wild-type mice. These 2 dystrophic features were less accentuated in young female than in young malemdxmice (−32% and 42% force drop). With advancing age, force-generating capacity decreased and fragility increased in old (20 month) femalemdxmice (−21% and 57% force decline), but they were unchanged in old malemdxmice. Moreover, estradiol treatment had no effect in old femalemdxmice.

Conclusions:

Female gender–related factors mitigate dystrophic features in young but not oldmdxmice. Further studies are warranted to identify the beneficial gender-related factor in dystrophic muscle. Muscle Nerve, 2013

Related Topics

    loading  Loading Related Articles