Effect of thyroliberin on the course of experimental candidosis in miceThyroliberin-Wirkung auf den Verlauf der experimentellen Candidose der Maus


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Abstract

SummaryThyroliberin (TRH) is one of the hormones, which affect immunologic processes. This hormone was studied in experimental subacute candidosis in mice. BALB/c males were given intraperitoneally single dose of Candida albicans cells (1 × 107 to 1 × 109 cfu of strain no. 244–33 ATCC). The animals from the experimental groups were injected subcutaneously, after 24 h from inoculation, dose of 10 μg TRH in 0.2 ml 0.9% NaCl, seven times at 24 h intervals. The control animals were given respectively 0.2 ml of physiologic NaCl solution. We have found that the examined hormone significantly decreases mortality in these animals (LD50C. albicans for mice treated with TRH was three times higher than that in the control groups), prolongs mean survival time for mice and decreases the intensity of fungal invasion of the animal organs.ZusammenfassungThyroliberin (TRH) ist ein Hormon, das Immunprozesse beeinflusst. Dies wurde am Modell der subakuten Candidose der Maus untersucht. Sieben Dosen von 10 μg TRH, subkuten 24 h nach Candida albicans Infektion in 24 h-Intervallen verabreicht, verminderten die Mortalität der Mäuse um den Faktor 3, verlängerten die Überlebenszeit der Tiere und verminderten die Organbeladung mit Candida-Zellen.

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