Modest efficacy of voriconazole against murine infections bySporothrix schenckiiand lack of efficacy againstSporothrix brasiliensis

    loading  Checking for direct PDF access through Ovid


SummaryThe efficacy of voriconazole (VRC) was evaluated against two strains of each of the two most common species causing sporotrichosis, Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, using a murine model of disseminated infection. Voriconazole was administered at doses of 20 or 40 mg kg−1 per day by gavage. The drug showed some efficacy, especially at 40 mg kg−1 per day, in prolonging the survival and reducing fungal load in spleen and liver in mice infected with S. schenckii, whereas in animals infected with S. brasiliensis the drug did not work.

    loading  Loading Related Articles