Gene expression profiling and histomorphometric analyses of the early bone healing response around nanotextured implants

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Abstract

While in vitro studies have shown that nanoscale surface modifications influence cell fate and activity, there is little information on how they modulate healing at the bone–implant interface.

Aim:

This study aims to investigate the effect of nanotopography at early time intervals when critical events for implant integration occur.

Materials & methods:

Untreated and sulfuric acid/hydrogen peroxide-treated machined-surface titanium alloy implants were placed in rat tibiae. Samples were processed for DNA microarray analysis and histomorphometry.

Results:

At both 3 and 5 days, the gene expression profile of the healing tissue around nanotextured implants differed from that around machined-surface implants or control empty holes, and were accompanied by an increase in bone–implant contact on day 5. While some standard pathways such as the immune response predominated, a number of unclassified genes were also implicated.

Conclusion:

Nanotexture elicits an initial gene response that is more complex than suspected so far and favors healing at the bone–implant interface.

Conclusion:

Original submitted 8 May 2012; Revised submitted 7 September 2012; Published online 3 January 2013

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