The sexual identity of adult intestinal stem cells controls organ size and plasticity

    loading  Checking for direct PDF access through Ovid


Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realization that cell-intrinsic mechanisms play important and persistent roles1,2. Here we use theDrosophila melanogasterintestine to investigate the nature and importance of cellular sex in an adult somatic organin vivo. We find that the adult intestinal epithelium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex differences in expression of genes with roles in growth and metabolism. Cell-specific reversals of the sexual identity of adult intestinal stem cells uncovers the key role this identity has in controlling organ size, reproductive plasticity and response to genetically induced tumours. Unlike previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise from intrinsic mechanisms that control cell cycle duration and involve a newdoublesex- andfruitless-independent branch of the sex differentiation pathway downstream oftransformer. Together, our findings indicate that the plasticity of an adult somatic organ is reversibly controlled by its sexual identity, imparted by a new mechanism that may be active in more tissues than previously recognized.

Related Topics

    loading  Loading Related Articles