BLADDER CANCER: Pioglitazone—when is a prescription drug safe?

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In a recent issue ofJAMA, Lewiset al.present long-term data on the likelihood of a link between pioglitazone and the risk of bladder cancer and ten other cancers. Their findings contradict previous concerns regarding the safety of pioglitazone, and add to the controversy surrounding interpretation of rare adverse events associated with prescription drugs.

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